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Literature summary extracted from
- Differential binding of factor XII and activated factor XII to soluble and immobilized fibronectin--localization of the Hep-1/Fib-1 binding site for activated factor XII (2008), FEBS J., 275, 5161-5172.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.38 | corn trypsin inhibitor | inhibits the activity of FXIIa, and thus the autoactivation of FXII | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.38 | extracellular matrix | FXIIa, but not FXII, binds to the extracellular matrix | Homo sapiens | 31012 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.38 | 80000 | - |
proenzyme FXII, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.38 | additional information | Homo sapiens | FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.38 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.38 | HUVEC cell | - |
Homo sapiens | - |
| 3.4.21.38 | umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.38 | factor XI + H2O | - |
Homo sapiens | factor XIa + ? | - |
? | |
| 3.4.21.38 | additional information | FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.38 | factor XII | - |
Homo sapiens |
| 3.4.21.38 | FXII | FXII is a zymogen of the proteolytically active FXIIa that plays a role in thrombus stabilization by enhancing clot formation and in inflammation by enhancing bradykinin formation | Homo sapiens |
| 3.4.21.38 | FXIIa | activated factor XII | Homo sapiens |
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